Role of nutraceuticals in cancer chemosensitization

Machine generated contents note: 1.Pathways Linked to Cancer Chemoresistance and Their Targeting by Nutraceuticals / Bharat Bhushan Aggarwal

Abstract

Introduction

Chemotherapy

Chemoresistance: Problem in Curing Cancer

Mechanism of Chemoresistance

Chemosensitization: An Approach to Target Cancer

Nutraceuticals as Chemosensitizers: Opportunities and Challenges

Conclusion

Conflict of Interest

Acknowledgments

References

2.The Potential of Curcumin: A Multitargeting Agent in Cancer Cell Chemosensitization / Ajaikumar B. Kunnumakkara

Abstract

Introduction

Chemosensitization Studies of Curcumin in Different Cancers

Conclusion

Conflict of Interest

Acknowledgment

References

Further Reading

3.Role of Resveratrol in Chemosensitization of Cancer / Kuzhuvelil B. Harikumar

Abstract

Introduction

Source and Chemistry of Resveratrol

Possible Molecular Mechanisms of Chemoresistance in Cancer

Note continued: Chemosensitization Studies Using Resveratrol in Vitro

Chemosensitization Studies Using Resveratrol in Vivo

Human Clinical Trials Involving Resveratrol in Cancer

Conclusion and Future Perspective

References

Further Reading

4.Role of Tocotrienols in Chemosensitization of Cancer / Mokenge P. Malafa

Abstract

Introduction

Source and Chemistry of Tocotrienols

Molecular Targets of Tocotrienols in Cancer

Mechanisms of Anticancer Action of Tocotrienols

Chemosensitization by Tocotrienols

Chemosensitization In Vitro

Chemosensitization In Vivo

Chemosensitization in Human

Conclusion

References

5.Chemosensitization by Ursolic Acid: A New Avenue for Cancer Therapy / Bharat Bhushan Aggarwal

Abstract

Introduction

Chemosensitization of Cancer Cells

Safety and Efficacy

Conclusion and Future Direction

Acknowledgment

References

6.Role of Fisetin in Chemosensitization / Bokyung Sung

Abstract

Note continued: Introduction

Chemistry and Sources of Fisetin

Molecular Targets of Fisetin

Chemosensitization by Fisetin

Conclusion

Conflict of Interest

References

7.Role of Celastrol in Chemosensitization of Cancer / Gautam Sethi

Abstract

Introduction

Biological Source of Celastrol and Its Chemistry

Molecular Targets of Celastrol and Its Potential Mechanism(s) of Action

Anticancer and Chemosensitizing Effects of Celastrol

Conclusions

Conflict of Interest

Acknowledgments

References

8.Role of Gambogic Acid in Chemosensitization of Cancer / Manoj K. Pandey

Abstract

Introduction

Source and Chemistry of GA

Molecular Targets of GA

Chemo-Sensitization by GA

Conclusion

References

9.Role of Catechins in Chemosensitization / Anju Shrivastava

Abstract

Introduction

Sources of Catechins

Structure and Chemistry of Catechins

Molecular Targets of the Catechin

Chemosensitization in Vitro

Note continued: Chemosensitization in Vivo

Human Trials

Implication of Catechins in Other Diseases

Conclusion

Conflict of Interest

Acknowledgment

References

Further Reading

10.Anticancer Attributes of Silibinin: Chemo- and Radiosensitization of Cancer / Rana P. Singh

Abstract

Introduction

Structural Composition and Bioavailability of Silymarin/Silibinin

Targeting of Various Attributes of Cancer Growth and Progression

Silibinin as Chemosensitizer for Cancer Cells

Silibinin as Radiosensitizer for Cancer Cells

Conclusions

References

11.Berberine as an Adjuvant and Sensitizer to Current Chemotherapy / Anjali Bhat

Abstract

Introduction

Source and Chemistry

Evidence Showing the Potential of Berberine as a Chemosensitizer

Hormetic Effects of Berberine in In Vitro Studies

Chemosensitization In Vivo and Other Beneficial Properties

Berberine in Human Trials

Conclusion

Conflict of Interest

Note continued: Acknowledgments

References

12.Role of Emodin in Chemosensitization of Cancer / Vipin Rai

Abstract

Introduction

Anti-cancer Activities of Emodin

Anti-cancer Activities of Emodin Analogues

Chemosensitization of Tumors by Emodin

Conclusions

Acknowledgments

References

13.Role of Piperine in Chemoresistance / Navneet Agnihotri

Abstract

Introduction

Sources and Chemistry of Piperine

Piperine Extraction and Quantification

Medicinal & Pharmacological Activities of Piperine

Mechanism of Action of Piperine

Chemoresistance and Chemosensitisation

Interactions of Piperine With Chemotherapeutic Drugs

Conclusion

References

Further Reading

14.Role of Deguelin in Chemoresistance / Shivakumari Asha Nair

Abstract

Introduction

Source and Chemistry of Deguelin

Molecular Targets of Deguelin

Chemosensitization by Deguelin

Conclusion

Acknowledgements

References

Note continued: 15.Garcinol: Preclinical Perspective Underpinning Chemo- and Radiosensitization of Cancer / Shivani B. Paruthy

Abstract

Introduction

Garcinol Bioavailability

Garcinol: Therapeutic Targets

Systemic Anticancer and Chemo-Sensitizing Effects of Garcinol

Garcinol and TRAIL Sensitization

Garcinol and Radiosensitization

Garcinol Combination With Other Natural Agents' on Cancer Therapy

Conclusion

References

16.Chemopreventive and Anticancer Effects of Plumbagin: Novel Mechanism(s) via Modulation of Cellular Redox / Santosh K. Sandur

Abstract

Introduction

Occurrence and Isolation of Plumbagin

Antioxidant Properties of Plumbagin

Chemopreventive and Antitumor Properties of Plumbagin

Antiangiogenic Property of Plumbagin

Plumbagin Nano-Particle Preparations

Anti-inflammatory Properties of Plumbagin

Chemosensitizing Properties of Plumbagin

Conclusion

References